TABLE 1.
Bactericidal titers of animal sera against N. meningitidis strain K454
| Serum | Antigen | Iron-limited growth of target bacteria? | Serum bactericidal titera |
|---|---|---|---|
| Mouse | TbpA | Yes | <4 |
| TbpA | No | <4 | |
| TbpB | Yes | <4 | |
| TbpB | No | <4 | |
| TbpA + TbpB | Yes | <4 | |
| TbpA + TbpB | No | <4 | |
| Rabbit | TbpA | Yes | 8, 16 |
| TbpA | No | 4 | |
| TbpB | Yes | 512 | |
| TbpB | No | 4 |
a
Bactericidal titers are expressed as the reciprocal of the last dilution of sera at which ≥50% of the inoculum is lysed. A pool of sera from five mice or serum from a single rabbit was tested for each antigen. Assays were performed twice. Where the repeat result did not match that of the first, both results are listed.