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Histopathology of primary leptomeningeal melanoma. (a) Hematoxylin and Eosin stained sections show sheets of medium-sized polygonal cells with moderately pleomorphic nuclei (white arrows) containing dispersed chromatin, macronucleoli, and moderate amounts of eosinophilic cytoplasm. (b) Immunoperoxidase staining for Melan A shows diffuse cytoplasmic staining (white arrows) in tumor cells. (c) Positive staining for Ki-67 (white arrows) is observed.
