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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Cell Rep. 2018 Oct 30;25(5):1359–1370.e4. doi: 10.1016/j.celrep.2018.09.091

Figure 7. Activity Levels Drop over Time with Progressing Niacin Deficiency.

Figure 7.

The physical activity of animals was measured as distance traveled in an open field test (m/5 min) and as number of ambulatory beam breaks.

(A) ANDY/DOX/ND1 distance traveled dropped significantly over time on diet compared to ANDY/DOX/CD1. One-way ANOVA with post-test for linear trend indicated a significant linear decline of activity (slope of −3.658, p = 0.034) in NAD+-deficient males compared to controls. Data represent mean ± SEM.

(B) Less locomotion indicated by fewer ambulatory beam breaks in NAD+-deficient males compared to controls; n = 5 per group; Student’s t test and 1-way ANOVA. Data represent box and whisker blots with Tukey’s whiskers.

*p < 0.05, **p < 0.01.