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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Nature. 2022 Apr 8;604(7906):509–516. doi: 10.1038/s41586-022-04556-w

Extended Data Figure 2. Schizophrenia case-control enrichment in constrained genes (pLI > 0.9) stratified by different variant annotations and inferred consequences (n = 22,444 cases and n = 39,837 controls).

Extended Data Figure 2.

LoF: all loss-of-function or PTVs; LoFHC: high-confidence LOFTEE PTVs; LoFLC: low-confidence based on LOFTEE; MPC > 3: missense variants with MPC > 3; MPC 2 – 3: missense variants with MPC 2 – 3; Other missense: missense variants with MPC < 2; Syn: synonymous variants. The dot represents the odds ratio, and the bars represent the 95% CIs of the point estimates.