Table 1.
Comparison of 68Ga-NOTA-Nb109 and 68Ga-NODA-CDV-Nb109.
| Analytes | Labeling method | Homogeneous structure | RCY (%) | RCP (%) | Molar activity (GBq/mol) | RCP of probe in serum for 2 h (%) | RCP of probe in PBS for 2 h (%) | Maximum tumor uptake of A375-hPD-L1 (%ID/mL) | Maximum tumor uptake of U87 (%ID/mL) | Maximum T/M ratio in A375-hPD-L1 | Maximum T/M ratio in U87 | Refs. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 68Ga-NOTA-Nb109 | Random | No | >95 | >98 | 25.17 ± 3.26 | >90 | >90 | 5.32 ± 0.47 | 2.84 ± 0.32 | 11.03 | 9.12 | [29,42] |
| 68Ga-NODA-CDV-Nb109 | Site-specific | Yes | >95 | >97 | 26.17 ± 3.32 | >90 | >90 | 4.99 ± 0.42 | 3.01 ± 0.52 | 5.84 | 4.40 | This work |
CDV: cysteine, aspartic acid, and valine; RCY: radiochemical yield; RCP: radiochemical purity; PBS: phosphate-buffered saline; T/M: tumor-to-muscle.