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. 2022 Dec 29;8(2):e002701. doi: 10.1136/rmdopen-2022-002701

Table 3.

Risk of GC-related and GC-unrelated organ damage development during 2-year follow-up across different patterns of GC tapering in 127 patients with newly diagnosed SLE starting concomitant hydroxychloroquine or immunosuppressants



GC-related damage GC-unrelated damage
Crude OR
(95% CI)
P Adj OR*
(95% CI)
P Crude OR (95% CI) P Adj OR*
(95% CI)
P
Tapering PDN <5 mg/day Ref. Ref. Ref. Ref.
Fail to taper PDN <5 mg/day 0.86 (0.21 to 3.22) 0.824 0.98 (0.20 to 4.45) 0.975 0.69 (0.25 to 1.81) 0.457 1.02 (0.32 to 3.24) 0.967
Never tapered PDN <5 mg/day 4.54 (1.47 to 15.10) 0.010 5.90 (1.53 to 27.0) 0.014 1.89 (0.71 to 5.03) 0.197 2.28 (0.70 to 7.57) 0.168

*Adjusted for age, gender, ECLAM score, baseline SDI and PDN daily dose.

ECLAM, European Consensus Lupus Activity Measurement; GC, glucocorticoid; PDN, prednisone; SLE, systemic lupus erythematosus.