Table 2.

IF-ANA staining patterns (HEp-2 cells) according to the ICAP nomenclature for the three diseases and as well as for HBDs

ICAP staining pattern	SLE: discovery cohort (n=282)	pSS (n=116)	SSc (n=57)	HBDs (n=236)
AC-0 (negative)	72 (25.5)	29 (25.0)	2 (3.5)	211 (89.4)
AC-1 (homogeneous)	104 (36.9)	30 (25.9)	8 (14.0)	9 (3.8)
AC-3 (centromere)	2 (0.7)	1 (0.9)	12 (21.1)	0 (0)
AC-4 (speckled)	41 (14.5)	36 (31.0)	17 (29.8)	6 (2.5)
AC-6 (multiple nuclear dots)	2 (0.7)	0 (0)	0 (0)	1 (0.4)
AC-8 (nucleolar)	10 (3.5)	1 (0.9)	1 (1.8)	4 (1.7)
AC-1+4	39 (13.8)	18 (15.5)	7 (12.3)	5 (2.1)
AC-1+4+8	2 (0.7)	0 (0)	2 (3.5)	0 (0)
AC-1+8	9 (3.2)	1 (0.9)	0 (0)	0 (0)
AC-4+7 (speckled+few nuclear dots)	0 (0)	0 (0)	1 (1.8)	0 (0)
AC-4+8	1 (0.35)	0 (0)	7 (12.3)	0 (0)

Percentages are given in parentheses.

HBDs, healthy blood donors; ICAP, International Consensus on ANA Patterns; IF-ANA, ANA detected with immunofluorescence microscopy; pSS, primary Sjögren’s syndrome; SSc, systemic sclerosis.