TABLE 3.
Protection of mice from a lethal challenge with pneumococci following passive immunization with rabbit polyclonal antisera raised against recombinant pneumococcal proteins
| Antigen | Motif | No. of survivors/total no.
|
|||||
|---|---|---|---|---|---|---|---|
| SJ2 (type 6B)
|
WU2 (type
3)
|
EF5668 (type 4)
|
|||||
| Specific serum | Nonspecific serum | Specific serum | Nonspecific serum | Specific serum | Nonspecific serum | ||
| Sp36 | SPase II | 10/10a | 1/10 | 9/10a | 0/10 | 5/10a | 0/10 |
| Sp46 | Choline-binding protein | 5/10a | 1/10 | NDb | ND | ||
| Sp91 | Choline-binding protein | 2/10 | 1/10 | 7/10a | 0/10 | ND | |
| Sp130 | Cell wall anchor | 2/10 | 2/10 | 7/10a | 0/10 | ND | |
a
Significantly different from the value for the nonspecific serum group (P < 0.05).
b
ND, not determined.