Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 2;11:3. doi: 10.1038/s41413-022-00243-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — Oln inhibits OA progression in a Fap-dependent manner. a–c Safranin O/Fast Green staining in control, Oln KO and Oln/Fap double KO mouse knee joints 8 weeks after DMM surgery. DMM surgery was performed in 10-week-old mice. Representative cartilage erosion (a, top: femur, bottom: tibia), subchondral bone thickening (b) and synovitis (c) images are shown (n = 7–9 mice per genotype). Yellow dotted lines indicate the subchondral bone plate. Arrows indicate the synovium. Scale bars: 100 μm. d–f Quantification of the OARSI score (d), subchondral bone thickness (e) and synovitis score (f). g, h Immunostaining of Col II in the knee joints (g) with quantification (h) (n = 6 mice per genotype). DAPI staining indicates the nucleus. Scale bars: 100 μm. The statistical significance was assessed using one-way ANOVAs with Tukey’s multiple comparison tests. Data are presented as the mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001)