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. 2023 Jan 2;8:3. doi: 10.1038/s41392-022-01225-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Administration of oxytocin analogue, dexamethasone and aspirin restores immune response and social behavior in zebrafish. a Experimental set-up and drugs exposure to 1-day-old embryos. Zebrafish larvea are performed with different concentration drugs (carbetocin, dexamethasone, or aspirin), respectively. qRT-PCR analysis of the relative transcription level of IL-1β at 2 dpf upon three groups. b Carbetocin, DXMS, and aspirin markedly decreases expression of pro-inflammatory cytokines IL-1β, Ctl, egg-water administration, Carbe 0.5 μM, Carbetocin 0.5 μM treatment; Carbe 1 μM, Carbetocin 1 μM treatment; DXMS 1 μM, dexamethasone 1 μM treatment; Aspirin 1 μM, Aspirin 1 μM treatment; Aspirin 10 μM, Aspirin 10 μM treatment. +/+: scgn^+/+, +/−: scgn^+/−, −/−: scgn^−/−. DXMS Dexamethasone, a synthetic corticosteroid used to treat inflammation, Aspirin also known as acetylsalicylic acid. P-values were calculated using one-way ANOVA, Tukey’s multiple comparisons test. ****p < 0.0001. Ns, not significant. c Six-day-old embryos were exposed to drugs for 2 days, respectively. IL-6 level and social behavior tests were performed on 8 dpf. d Carbetocin, DXMS and aspirin markedly decreases expression of IL-1β. P-values were calculated using one-way ANOVA, Tukey’s multiple comparisons test. ****p < 0.0001. Ns not significant. e Contact frequency in larvea are rescued with Carbetocin and aspirin administration. +/+: scgn^+/+, −/−: scgn^−/−. P-values were calculated using one-way ANOVA, Tukey’s multiple comparisons test. ****p < 0.0001. *p < 0.05. f Duration of larvae body contact can be rescued with Carbetocin and aspirin administration. +/+: scgn^+/+, −/−: scgn^−/−. P-values were calculated using one-way ANOVA, Tukey’s multiple comparisons test. ****p < 0.0001.*p < 0.05