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. 2022 Dec 19;13:1083462. doi: 10.3389/fimmu.2022.1083462

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Copyright © 2022 Li and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADCC process including NK cells, mAb, and tumor cells. The mAbs include the Fab and Fc segments. The Fab segment is an endometrioid by heavy-chain constant region (C_H1) and heavy chain variable region (V_H), in which the amino acid sequence is constant. The amino acid sequences of light-chain constant region (C_L) and heavy-chain variable region (V_L) sites are variable. Complementary determining regions (CDRs) of the Fab segment bind on tumor cells by different amino acid sequences, such as trastuzumab binding to HER2 extracellular region IV. The Fc segment includes C_H2 and C_H3. NK cells bind to the Fc segment of mAb via CD16. CD16 interacts with C_H2 of mAb in a 1:1 manner, where the N-glycan chain at the N297 position on C_H2 also plays a key role in this interaction.