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Zc3h13 modulates RNA m6A methylation in the nucleus. Zc3h13 anchors WTAP, Virilizer, and Hakai in the nucleus to facilitate m6A methylation and to regulate mESC self-renewal. Upon Zc3h13 knockdown, a great majority of WTAP, Virilizer, and Hakai translocate to the cytoplasm to inhibit m6A methylation.
