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. 2022 Dec 19;10:989932. doi: 10.3389/fbioe.2022.989932

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Copyright © 2022 Goncharov, Kovalskaia, Romanishin, Shved, Belousov, Tiasto, Gulaia, Neergheen, Rummun, Liskovykh, Larionov, Kouprina and Kumeiko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the cell cycle after PLE treatment. (A) Flow cytometry analysis of HT1080 untreated cells 24 and 72 h after PLE treatment. (B) The percentage of cells in G1, S and G2/M phases in HT1080 cell population after 24 and 72 h. (C) Flow cytometry analysis of RPE-1 untreated cells after 24 and 72 h. (D) The percentage of cells in G1, S and G2/M phases in RPE-1 cell population after 24 and 72 h. The statistical analysis was performed using 2way ANNOVA, asterisks indicate statistical significance (****p < 0,0001, relative to the negative control—untreated cells).