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. 2022 Dec 19;10:989932. doi: 10.3389/fbioe.2022.989932

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Copyright © 2022 Goncharov, Kovalskaia, Romanishin, Shved, Belousov, Tiasto, Gulaia, Neergheen, Rummun, Liskovykh, Larionov, Kouprina and Kumeiko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Accumulation of γH2AX foci in HT1080 and RPE-1 cells treated with PLE. (A) γH2AX immunostaining of HT1080 cells before and after treatment with PLE. (B) The percentage of γH2AX foci in HT1080 and RPE-1 cells. As a positive control, we used Etoposide – a drug commonly used for cancer therapy. Etoposide is an inhibitor of topoisomerase II that forms DSBs (Tassanee Lerksuthirat et all., 2020). Error bars correspond to a standard deviation (SD) of four replicates. Statistical analysis was performed using 2way ANNOVA, asterisks indicate statistical significance (***p < 0.001, ****p < 0.0001, relative to the negative control—untreated cells).