Table 4.

Cox Regression Model for Predicting MACE in ACS Patients Undergoing PCI According to One Standard Deviation (SD) Increases in Blood Cell Count-Derived Inflammation Indices.

Inflammation indices as a continuous variable (per 1-SD increase)	Model 1		Model 2		Model 3
	HR (95%CI)	P-value	HR (95%CI)	P-value	HR (95%CI)	P-value
AISI	1.277 (1.101-1.481)	.001	1.271 (1.098-1.471)	.001	1.140 (0.955-1.360)	.146
SIRI	1.282 (1.153-1.426)	<.001	1.312 (1.172-1.470)	<.001	1.208 (1.045-1.397)	.011
NLRP	1.038 (0.898-1.201)	.611	1.014 (0.877-1.174)	.847	1.006 (0.854-1.185)	.941

Abbreviations: MACE, major adverse cardiovascular events; ACS, acute coronary syndrome; PCI, percutaneous coronary intervention; HR, hazard ratio; CI, confidence interval; AISI, aggregate index of systemic inflammation (neutrophil*platelet* monocyte-to-lymphocyte ratio); SIRI, systemic inflammation response index (neutrophil*monocyte-to-lymphocyte ratio); NLRP, neutrophil-to-(lymphocyte*platelet) ratio; BMI, body mass index; CAD, coronary artery disease; CGS, cardiogenic shock; HF, heart failure; Cr, creatinine; LA, left atrium; LVEF, left ventricular ejection fraction; ALB, albumin.

Model 1: Unadjusted.

Model 2: Adjusted for sex, age>65 years, BMI.

Model 3: Adjusted for terms in Model 2 and smoking, dyslipidemia, hypertension, diabetes mellitus, history of stroke, family history of CAD, CGS, HF, Cr, LVEF <40%, and ALB<40.72.