Table 5.
Cox Regression Model for Predicting MACE in ACS Patients Undergoing PCI According to Tertiles of Blood Cell Count-Derived Inflammation Indices.
| Inflammation indices as a nominal variable (tertiles 1-3) | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | ||
| AISI | T1 | 1 (Reference) | — | 1 (Reference) | — | 1 (Reference) | — |
| T2 | 1.596 (0.768-3.317) | .210 | 1.570 (0.755-3.264) | .227 | 1.587(0.728-3.457) | .245 | |
| T3 | 2.808 (1.440-5.476) | .002 | 3.004 (1.535-5.880) | .001 | 2.345 (1.141-4.819) | .020 | |
| P for trend | .002 | <.001 | .017 | ||||
| SIRI | T1 | 1 (Reference) | — | 1 (Reference) | — | 1 (Reference) | — |
| T2 | 1.427 (0.675-3.017) | .352 | 1.436 (0.675-3.053) | .348 | 1.189 (0.535-2.644) | .671 | |
| T3 | 2.966 (1.531-5.746) | <.001 | 3.118 (1.586-6.131) | <.001 | 2.135 (1.023-4.455) | .043 | |
| P for trend | <.001 | <.001 | .025 | ||||
| NLRP | T1 | 1 (Reference) | — | 1 (Reference) | — | 1 (Reference) | — |
| T2 | 2.497(1.150-5.424) | .021 | 2.471(1.131-5.399) | .023 | 2.202(0.955-5.074) | .064 | |
| T3 | 3.606(1.711-7.600) | <.001 | 3.424(1.601-7.322) | .002 | 2.599(1.116-6.048) | .027 | |
| P for trend | <.001 | .001 | .033 | ||||
Abbreviations: MACE, major adverse cardiovascular events; ACS, acute coronary syndrome; PCI, percutaneous coronary intervention; HR, hazard ratio; CI, confidence interval; AISI, aggregate index of systemic inflammation (neutrophil*platelet*monocyte-to-lymphocyte ratio); SIRI, systemic inflammation response index (neutrophil*monocyte-to-lymphocyte ratio); NLRP, neutrophil-to-(lymphocyte*platelet) ratio; BMI, body mass index; CAD, coronary artery disease; CGS, cardiogenic shock; HF, heart failure; Cr, creatinine; LA, left atrium; LVEF, left ventricular ejection fraction; ALB, albumin.
Model 1: Unadjusted.
Model 2: Adjusted for sex, age>65 years, BMI.
Model 3: Adjusted for terms in Model 2 and smoking, dyslipidemia, hypertension, diabetes mellitus, history of stroke, family history of CAD, CGS, HF, Cr, LVEF <40%, and ALB<40.
AISI: T1 (<199.94), T2 (199.94-425.60), T3 (>425.60).
SIRI: T1 (<0.98), T2 (0.98-2.00), T3 (>2.00).
NLRP: T1 (<0.011), T2 (0.011-0.023), T3 (>0.023).