TABLE 3.
Action potential characteristics.
| Target holding potential (n) | [Cinacalcet] (µM) | Recorded hold. pot. (mV) | Input res. (MΩ) | Action pot. threshold (mV) | Action pot. amp. (mV) | Action pot. half-width (ms) |
|---|---|---|---|---|---|---|
| −80 mV (9) | 0 | −80.2 ± 1.2 | 482 ± 49 | −47.6 ± 1.6 | 67.9 ± 1.8 | 1.4 ± 0.7 |
| 2 | −80.3 ± 0.8 | 493 ± 35 | −49.4 ± 1.6 | 64.5 ± 2.0 | 1.4 ± 0.9 | |
| 5 | −81.2 ± 0.5 | 506 ± 45 | −48.5 ± 3.5 | 55.8 ± 5.1 | 1.7 ± 0.1 | |
| −70 mV (11) | 0 | −70.6 ± 0.6 | 347 ± 32 | −45.1 ± 1.2 | 64.9 ± 1.7 | 1.5 ± 0.1 |
| 2 | −70.5 ± 0.3 | 354 ± 32 | −45.4 ± 1.3 | 58.3 ± 4.0 | 1.8 ± 1.9 | |
| 5 | −70.9 ± 0.3 | 349 ± 31 | −44.2 ± 1.8 | 44.2 ± 4.3 | 2.5 ± 0.3 | |
| −60 mV (10) | 0 | −63.4 ± 1.3 | 265 ± 48 | −44.5 ± 1.6 | 65.5 ± 3.9 | 2.1 ± 0.3 |
| 2 | −61.9 ± 0.7 | 244 ± 33 | −44.2 ± 1.4 | 56.5 ± 4.9 | 3.2 ± 1.1 | |
| 5 | −61.1 ± 0.7 | 243 ± 30 | −40.8 ± 2.2 | 45.8 ± 5.5 | 4.0 ± 1.3 | |
| Test | 2W- ANOVA RM | Mixed effects model | Mixed effects model | Mixed effects model | ||
| Probability of interaction | 0.598 | 0.336 | <0.001 | 0.236 | ||
| Probability of cina. effect | 0.969 | 0.191 | <0.001 | 0.009 | ||
| Probability of hold. pot. effect | <0.001 | 0.100 | <0.001 | 0.130 |