Table 1.
Demographic characteristics of participants in discovery and validation cohorts.
| Clinical indices | Discovery cohort | Validation cohort | ||||
|---|---|---|---|---|---|---|
| DKD(n=120) | DMHC(n=232) | P-Value | DKD(n=60) | DMHC(n=116) | P-Value | |
| Gender | 0.063 | 0.172 | ||||
| Male | 75 | 121 | 37 | 59 | ||
| Female | 45 | 111 | 23 | 57 | ||
| Age | 56(49, 62) | 51(46, 57) | <0.001 | 55±12 | 52±10 | 0.077 |
| DM course(month) | 114(36, 180) | 0(0, 23) | <0.001 | 90(8, 156) | 0(0, 8) | <0.001 |
| eGFR(mL/min) | 50.11(25.19, 94.86) | 101.94(93.01, 107.97) | <0.001 | 61.86(25.81, 97.75) | 101.11(94.96, 107.78) | <0.001 |
| SBP(mmHg) | 139.4±18.3 | 122.7±15.1 | <0.001 | 135(124, 150) | 122(113, 129) | <0.001 |
| DBP(mmHg) | 80.7±10.1 | 75.8±9.7 | <0.001 | 82±13 | 75±9 | 0.001 |
| Ghb(%) | 7.39(6.60, 8.74) | 5.57(4.87, 5.94) | <0.001 | 7.59(6.68, 8.93) | 5.60(5.02, 6.00) | <0.001 |
| 24h-pro(g) | 2.94(0.60, 6.01) | 0.06(0.06, 0.13) | <0.001 | 1.93(0.75, 5.03) | 0(0, 0.02) | <0.001 |
| Cr(μmol/L) | 120.5(74.0, 237.7) | 65.0(55.0, 76.0) | <0.001 | 101.5(71.0, 218.4) | 62.0(55.5, 75.3) | <0.001 |
| Alb(g/L) | 35.7(28.3, 40.7) | 45.9(42.0, 48.1) | <0.001 | 34.9±7.3 | 43.3±10.2 | <0.001 |
| DKD(n=180) | DM(n=138) | |||||
| BMI(kg/m2) | 24.82(23.91-25.38) | 24.79(22.51-26.24) | 0.115 | |||
Normal distribution was measured by K-S test. Subsequent analysis between groups were completed by LSD t-test. Variances between DN and MN were analyzed by t-test. χ2 test was used to compare categorical variables. DM course, course of diabetes mellitus; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; Ghb, glycosylated hemoglobin; 24h-pro, 24-h urine protein; Cr, creatinine; Alb, serum albumin. BMI, body mass index.