Table 2.
The potentially harmful significantly accumulated genus shared by both DKD when compared with DMHC and DKD5 when compared with other DKD stages.
| Genus | DKD V.S. DMHC | DKD5 V.S. Other stages | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| DKD mean abundance | DMHC mean abundance | P-Value | Significance mark | DKD1&2 mean abundance | DKD3 mean abundance | DKD4 mean abundance | DKD5 mean abundance | P-Value | Significance mark | |
| Christensenellaceae_R-7_group | 0.016780475 | 0.00634137 | <0.001 | *** | 0.00727363 | 0.01963563 | 0.01410525 | 0.02846495 | 0.01374242 | * |
| Oscillospiraceae_UCG-005 | 0.009059783 | 0.00383319 | <0.001 | *** | 0.00229413 | 0.00328644 | 0.00633195 | 0.0267505 | 0.00208477 | ** |
| [Eubacterium]_siraeum_group | 0.003143658 | 5.10E-04 | <0.001 | *** | 3.46E-05 | 9.68E-04 | 0.00333049 | 0.00541825 | <0.001 | *** |
| Ruminococcaceae_Incertae_Sedis | 0.001846742 | 7.17E-04 | <0.001 | *** | 7.87E-04 | 0.00108463 | 0.00136208 | 0.0047221 | 0.00860697 | ** |
| Eisenbergiella | 0.00259155 | 5.45E-05 | <0.001 | *** | 7.21E-04 | 8.13E-05 | 1.08E-04 | 0.01478735 | 0.01056184 | * |
| [Clostridium]_methylpentosum_group | 2.30E-04 | 4.13E-05 | <0.001 | *** | 6.79E-05 | 3.89E-05 | 2.36E-04 | 4.25E-04 | 0.02048064 | * |
| Candidatus_Soleaferrea | 1.48E-04 | 3.63E-05 | <0.001 | *** | 4.13E-05 | 1.10E-04 | 1.07E-04 | 3.75E-04 | 0.02619775 | * |
| Pygmaiobacter | 1.20E-04 | 4.63E-06 | <0.001 | *** | 7.13E-06 | 8.88E-06 | 1.04E-04 | 3.12E-04 | 0.00382388 | ** |
| Anaerofustis | 2.30E-05 | 3.68E-06 | <0.001 | *** | 3.29E-05 | 1.61E-05 | 1.32E-05 | 6.21E-05 | 0.025791 | * |
| [Eubacterium]_coprostanoligenes_group | 0.020859025 | 0.01300594 | 0.00369213 | ** | 0.00383125 | 0.00837588 | 0.02203784 | 0.03317715 | 0.04111925 | * |
| Ruminococcaceae_CAG-352 | 0.012251092 | 0.00535581 | 0.0022268 | ** | 7.65E-04 | 0.00393394 | 0.01322849 | 0.0197852 | 0.0249018 | * |
| Moryella | 1.12E-04 | 6.25E-05 | 0.00481505 | ** | 7.03E-05 | 1.19E-04 | 8.25E-05 | 2.34E-04 | 0.00809893 | ** |
| Anaerofilum | 4.47E-05 | 1.05E-05 | 0.0027824 | ** | 3.00E-06 | 4.81E-06 | 2.78E-05 | 1.58E-04 | 0.00643322 | ** |
| Acetanaerobacterium | 1.71E-05 | 3.23E-06 | 0.00566189 | ** | 0 | 2.44E-06 | 1.77E-05 | 3.36E-05 | <0.001 | *** |
| Oscillospiraceae_UCG-002 | 0.021873833 | 0.01287019 | 0.02670477 | * | 0.00964975 | 0.00795313 | 0.01760568 | 0.054119 | 0.00702877 | ** |
| Negativibacillus | 5.16E-04 | 3.48E-04 | 0.04795034 | * | 9.89E-04 | 5.95E-05 | 3.62E-04 | 0.0012797 | <0.001 | *** |
DKD, Diabetic Kidney Disease; DMHC, Diabetes Mellitus and Healthy control; *P<0.05, **P<0.01, ***P<0.001.