Table 3.
The potentially harmful significantly accumulated OTUs shared by DKD when compared with DMHC, DKD5 when compared with other DKD stages, and DKD mice when compared with Con and FMT mice.
| OTUs | DKD V.S. DMHC | DKD5 V.S. Other stages | DKD rats V.S. Con & FMT rats | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DKD mean abundance | DMHC mean abundance | P-Value | Significance mark | DKD1&2 mean abundance | DKD3 mean abundance | DKD4 mean abundance | DKD5 mean abundance | P-value | Significance mark | Con mean abundance | DKD mean abundance | FMT mean abundance | P-value | ||
| OTU83 (Muribaculaceae) | 0.00190495 | 9.98E-04 | 0.00211266 | ** | 0 | 0 | 8.95E-07 | 2.10E-04 | 0.125067126 | 0 | 0.011061875 | 3.57E-06 | <0.001 | *** | |
| OTU303 (Ruminococcaceae_uncultured) | 1.93E-04 | 2.97E-05 | <0.001 | *** | 1.72E-04 | 5.06E-06 | 1.84E-04 | 3.88E-04 | 0.008703768 | ** | 1.16E-05 | 7.23E-04 | 1.97E-04 | <0.001 | *** |
| OTU105 (Flavobacteriaceae_uncultured) | 1.23E-05 | 2.45E-06 | 0.00121705 | ** | 0 | 7.44E-06 | 4.70E-06 | 4.99E-05 | 0.008009472 | ** | 2.74E-04 | 0.0021485 | 0.001269857 | 0.00226052 | ** |
| OTU154 (Subdoligranulum) | 1.19E-04 | 2.09E-06 | <0.001 | *** | 1.75E-05 | 0 | 3.44E-05 | 5.77E-04 | 0.010933308 | * | 0 | 0.002816375 | 0 | 0.00126895 | ** |
| OTU251 (Oscillospiraceae_UCG-002) | 0.015745408 | 0.006829418 | 0.00387515 | ** | 0.007366875 | 0.004258313 | 0.012553237 | 0.04041675 | 0.009132116 | ** | 0 | 0.002146375 | 0 | 0.00503556 | ** |
| OTU241 (Lachnospiraceae_unclassified) | 3.91E-05 | 5.72E-06 | <0.001 | *** | 0 | 1.20E-05 | 4.39E-05 | 5.83E-05 | <0.001 | *** | 0 | 0.001966875 | 0 | 0.00503556 | ** |
| OTU246 (Oscillospirales_UCG-010) | 6.36E-05 | 2.66E-05 | 0.01900196 | * | 0 | 1.31E-06 | 3.72E-05 | 2.39E-04 | 0.003385615 | ** | 5.43E-06 | 7.25E-04 | 2.64E-04 | 0.00275607 | ** |
| OTU176 (Christensenellaceae_R-7_group) | 0.001168783 | 1.28E-04 | <0.001 | *** | 1.30E-04 | 0 | 0.001441171 | 0.0014841 | 0.001131849 | ** | 0 | 5.87E-04 | 4.63E-05 | 0.00907164 | ** |
| OTU483 (Lachnospiraceae_unclassified) | 2.66E-04 | 1.93E-05 | <0.001 | *** | 8.08E-05 | 6.73E-05 | 1.23E-04 | 0.0010449 | <0.001 | *** | 0 | 1.37E-04 | 0 | 0.00126895 | ** |
| OTU529 (Christensenellaceae_R-7_group) | 5.88E-05 | 2.04E-05 | <0.001 | *** | 1.01E-05 | 2.18E-05 | 4.32E-05 | 1.67E-04 | 0.016998359 | * | 0 | 4.00E-05 | 0 | 0.00503556 | ** |
| OTU233 (Ruminococcaceae_unclassified) | 1.31E-05 | 3.02E-07 | <0.001 | *** | 0 | 0 | 6.92E-06 | 5.20E-05 | 0.006485023 | ** | 0 | 0.001572 | 1.67E-05 | 0.01628199 | * |
| OTU202 (Ruminococcaceae_unclassified) | 2.07E-05 | 9.35E-06 | 0.00189313 | ** | 0 | 0 | 2.04E-05 | 4.65E-05 | 0.005952553 | ** | 1.30E-05 | 3.74E-04 | 2.42E-04 | 0.02650222 | * |
| OTU140 ([Eubacterium]_siraeum_group) | 0.003044842 | 2.78E-04 | <0.001 | *** | 2.41E-05 | 9.68E-04 | 0.003240105 | 0.005173 | <0.001 | *** | 1.77E-04 | 2.18E-04 | 0 | 0.04239545 | * |
| OTU313 (Butyricicoccaceae_UCG-009) | 1.28E-05 | 1.29E-07 | <0.001 | *** | 1.78E-05 | 1.16E-05 | 3.83E-06 | 4.60E-05 | 0.040648438 | * | 4.43E-06 | 2.70E-04 | 7.00E-05 | 0.03125367 | * |
OTU, Operational Taxonomy Units; DKD, Diabetic Kidney Disease; DMHC, Diabetes Mellitus and Healthy control; Con, healthy control; FMT, Fecal Microbiota Transplantation; *P<0.05, **P<0.01, ***P<0.001.