Figure 5.

Therapeutic effects of iMVs-VCs on skin damage. (a) Experiment schematic. The skin damage model was established. After the surgery, the iMVs-VCs were injected intracutaneously. The mice were sacrificed for sample collection on day 3 and 30. (b) Pictures of skin on day 3 post-surgery. (c) Quantification of the length of regenerated epidermal tongue in different groups. (d) HE staining was performed to reveal pathological conditions of skin healing in different groups. Scale bar, 100 μm. (e) Masson staining indicated extracellular fibrotic collagen deposition in the damaged area. Scale bar, 100 μm. (f) Immunofluorescence of wound edges indicated the angiogenic capacity of iMVs-VCs by staining ECs (CD31 in green, VWF in red) on day 3. Scale bar, 200, 50 μm. Data are presented as the mean ± SD, n = 3/group, *p < 0.05, **p < 0.01.