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. 2022 Dec 28;18:100530. doi: 10.1016/j.mtbio.2022.100530

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 12 — Functional decellularized extracellular matrix in reproductive system repair. (A) Rabbit uterine decellularization. (i) Rabbit uterus before decellularization, and its tissue H&E, Masson's trichrome, and DAPI stain. (ii) After decellularization of the rabbit uterus and its tissue H&E, Masson's trichrome, and DAPI stain, it can be seen that the cells have been largely removed. Adapted reprinted with permission from Ref. [347], based on CC BY NC ND License. (B) UBM repairs the uterine horn in rats. (i) Appearance and structure of UBM. (ii) Appearance of the uterine horns in the experimental groups; (iii) Complete degradation of UBM material in the experimental groups after 4 weeks. Adapted reprinted with permission from Ref. [349], based on CC BY License. (C) Non-cross-linked and cross-linked dUECM subcutaneous embedding experiments were performed 14 days later for (i) histological observation (ii) and HE staining. Adapted reprinted with permission from Ref. [350], based on CC BY License.(D) Morphological observation of cross-linked dECM in the reconstructed uterus of rats in vivo. Adapted reprinted with permission from Ref. [350], based on CC BY License. Abbreviations: UBM: Urinary bladder matrix. dUECM:decellularized rabbit uterus matrix.