Fig. 7.

Functional decellularized extracellular matrix in nervous system repair. (A) Positive modulating effect of FUB-ECM on tissue remodeling after ION dissection repair. (i) Schematic of the ION cut and repair model showing the anastomosis and FUB-ECM nerve wrap. (ii) After 28 days, fUB-ECM nerve wraps remained sutured around the ION. (iii) H&E staining showed that in fUB-ECM cut-repair IONs, the organization resembled naïve IONs.Adapted reprinted with permission from Ref. [279], based on CC BY License. (B) ScI rat locomotor function assessments. (i) Movement of scI rats' hind limbs after FgF2-dscecM-hP hydrogel treatment, (ii) The Basso, Beattie, and Bresnahan scores, (iii) After various treatments, the scI rats' inclination angle [298]. (C) After 28 days of therapy, spinal cord-injured rats had nerve fiber healing and axonal regrowth. Adapted reprinted with permission from Ref. [298], based on CC BY License. (D) Growth-associated protein-43 expression is increased by FUB-ECM nerve wrapping during ION cut and repair. Adapted reprinted with permission from Ref. [279], based on CC BY License. (E) Insert shows surface CD206 labeling and intracellular CD68 labeling. In controlled portions, no further expansion of the proximal stump was seen. Adapted reprinted with permission from Ref. [293] (License number:5,442,480,428,926) Abbreviations:ION:infraorbital nerve. FUB-ECM: fetal porcine urinary bladder extracellular matrix. SCI: Spinal cord injury. FgF2:factor-2. DscecM: spinal cord extracellular matrix. hP：heparin-poloxamer.