Table 2.
Pathological analysis and topography of salvage radical prostatectomy
| Parameter | Result |
|---|---|
| Year of salvage radical prostatectomy, n (%) | |
| <2010 | 7 (17.0) |
| 2011–2015 | 17 (41.5) |
| 2016–2021 | 17 (41.5) |
| International Society of Urological Pathology grade group, n (%) | |
| Grade group 1 | 4 (9.8) |
| Grade group 2 | 7 (17.0) |
| Grade group 3 | 12 (29.3) |
| Grade group 4 | 3 (7.3) |
| Grade group 5 | 13 (31.7) |
| Not evaluable | 2 (4.9) |
| pT stage, n (%) | |
| pT2 | 22 (53.6) |
| pT3a | 7 (17.0) |
| pT3b | 12 (29.3) |
| Positive surgical margin status (R+), n (%) | 16 (39.0) |
| Unilateral | 10 (24.4) |
| Bilateral | 6 (14.6) |
| R+ focality | |
| Unifocal | 8 (19.5) |
| Multifocal | 8 (19.5) |
| R+ site a | |
| Apex | 9 (21.9) |
| Mid-gland | 7 (17.0) |
| Base | 7 (17.0) |
| R+ extent | |
| 1/3 segments | 10 (24.4) |
| 2/3 segments | 4 (9.8) |
| 3/3 segments | 2 (4.9) |
| Extracapsular extension, n (%) | 19 (46.3) |
| Anterior only | 0 (0.0) |
| Posterior only | 15 (36.6) |
| Anterior + posterior | 4 (9.7) |
| Laterality | |
| Unilateral | 10 (24.4) |
| Bilateral | 9 (21.9) |
| Site a | |
| Apex | 9 (21.9) |
| Mid-gland | 9 (21.9) |
| Base | 13 (31.7) |
| Extent | |
| 1/3 segments | 13 (31.7) |
| 2/3 segments | 1 (2.4) |
| 3/3 segments | 5 (12.2) |
| Focality | |
| Unifocal | 10 (24.4) |
| Multifocal | 9 (21.9) |
| Index lesion status, n (%) b | |
| Whole gland | 3 (7.3) |
| Solitary index lesion | 26 (63.4) |
| Unilateral/minor contralateral involvement | 13 (50.0) |
| Unilateral/minor contralateral involvement + nsPCa focus | 7 (27.0) |
| Unilateral/contralateral involvement >50% | 6 (23.0) |
| More than one index lesion | 12 (29.3) |
| Same quadrant | 3 (25.0) |
| Opposite quadrants | 9 (75.0) |
| Seminal vesicle invasion >1 cm | 9 (22.0) |
| Median maximum diameter of the index lesion, mm (IQR) | 17 (10–25) |
| Median maximum volume of the index lesion, cm3 (IQR) | 1.07 (0.3–3.0) |
| Median prostate volume, cm3 (IQR) | 31.4 (23.5–36.7) |
| Lesion distance from the urethra, n (%) | |
| Invasion | 11 (26.8) |
| <2 mm | 7 (17.0) |
| >2 mm | 23 (56.0) |
| Lesion distance from the apex, n (%) | |
| <3 mm | 28 (68.0) |
| >3 mm | 13 (32.0) |
| Lymph nodes | |
| Lymphadenectomy template, n (%) | |
| Limited | 29 (70.7) |
| Extended | 3 (7.3) |
| Superextended | 7 (17.0) |
| Median number of nodes taken, n (IQR) | 17 (11–28) |
| pN+ status, n (%) | 12 (29.3) |
| Median number of positive nodes, n (IQR) c | 2 (1.75–3) |
| Unilateral, n (%) | 10 (25.0) |
| Bilateral, n (%) | 2 (5.0) |
IQR = interquartile range; nsPCa = nonsignificant prostate cancer.
Percentage calculated according to the total number of salvage radical prostatectomies, and considering the positivity for individual areas. 1/3 segment = apex or mid-gland or base; 2/3 segments = apex and mid-gland, or apex and base, or mid-gland and base; 3/3 segments = apex, mid-gland, and base.
Percentages for lesion subgroups were calculated according to the number of patients belonging to the respective group; limited = external iliac and obturator nodes; extended = external iliac, internal iliac, obturator, and presacral nodes; superextended = extended template plus the retroperitoneum.
Calculated among the men with positive nodes.