Table 1.
Sleep variables found in control patients and participants taking SSRIs or bupropion.
| Control Patients (n = 17) | SSRIs (n = 10) | Bupropion (n = 6) | Kruskal–Wallis ANOVA | Mann–Whitney U Test, P < | ||||
|---|---|---|---|---|---|---|---|---|
| Median (IQR) | Median (IQR) | Median (IQR) | H2, n = 33 | P < | 1 vs 2 | 2 vs 3 | 1 vs 3 | |
| Time in bed, min | 476.0 (461.0–505.0) | 510.3 (476.5–549.5) | 486.8 (480.0–512.0) | 2.951 | NS | — | — | — |
| Sleep period time, min | 453.0 (439.0–492.0) | 470.3 (443.5–504.0) | 475.8 (432.5–493.5) | 1.091 | NS | — | — | — |
| Total sleep time, min | 428.5 (406.0–467.0) | 394.3 (326.0–434.0) | 401.0 (321.0–432.0) | 3.117 | NS | — | — | — |
| Sleep latency, min | 10.0 (6.0–13.0) | 37.0 (32.0–46.0) | 14.8 (5.5–19.0) | 11.248 | .0036 | 0.001 | 0.045 | NS |
| Stage R latency, min | 91.5 (67.5–120.5) | 123.8 (93.5–157.5) | 76.3 (57.5–94.0) | 3.762 | NS | — | — | — |
| Stage shifts/h | 5.5 (4.4–11.7) | 16.4 (12.2–22.9) | 12.0 (8.8–15.3) | 13.796 | .001 | 0.0007 | NS | 0.042 |
| Awakenings/h | 1.2 (0.8–3.9) | 4.2 (3.3–9.5) | 5.1 (4.6–5.5) | 7.230 | .027 | 0.02 | NS | NS |
| Sleep efficiency, % | 91.8 (87.4–93.4) | 73.6 (67.8–85.0) | 85.1 (78.4–88.1) | 8.717 | .013 | 0.0084 | NS | NS |
| Stage W, % | 3.9 (2.1–6.0) | 18.4 (8.0–28.0) | 11.2 (5.9–21.5) | 7.703 | .021 | 0.033 | NS | 0.019 |
| Stage N1, % | 5.0 (3.7–5.9) | 12.4 (7.9–17.0) | 8.6 (4.0–9.7) | 10.876 | .0043 | 0.0017 | NS | NS |
| Stage N2, % | 51.5 (44.0–55.3) | 35.9 (28.5–39.7) | 39.1 (36.9–58.0) | 7.646 | .022 | 0.0046 | NS | NS |
| Stage N3, % | 19.9 (17.8–24.9) | 14.8 (12.9–20.8) | 12.6 (10.2–16.9) | 7.361 | .025 | NS | NS | 0.013 |
| Stage R, % | 17.4 (12.3–21.6) | 16.6 (8.0–18.7) | 19.8 (16.3–21.9) | 1.296 | NS | — | — | — |
ANOVA = analysis of variance, IQR = interquartile range, SSRs = selective serotonin reuptake inhibitors.