TABLE 4.
Circulating levels of IL-12 induced by ODN administration
| Treatment | Day post challengea | Circulating IL-12 (pg/ml) | Mean (pg/ml) of circulating IL-12 |
|---|---|---|---|
| CpG ODN 1826 | 2 | 10,087 | 13,914 |
| 1 | 12,214 | ||
| 0 | 10,523 | ||
| 1 | 22,831 | ||
| Control ODN 1982 | 2 | 1,484 | 1,367 |
| 2 | 1,538 | ||
| 0 | 1,181 | ||
| 1 | 1,264 | ||
| Infectivity control | 1 | 105 | 389 |
| 1 | 418 | ||
| 1 | 168 | ||
| 1 | 863 |
a
CpG ODN (50 μg) was administered i.m. in the tibialis anterior muscle on day −2 relative to i.v. inoculation of sporozoites on day 0. Serum was collected from individual mice on the day indicated, relative to i.v. inoculation of sporozoites on day 0, and assayed for IL-12 level by enzyme-linked immunosorbent assay.