H. somnus induces ultrastructural apoptotic changes in endothelial cells. (A) Transmission electron micrograph of endothelial cells infected with H. somnus 8025 organisms for 6 h at an MOI of 10:1 that exhibited nucleic acid condensation (arrows). Magnification, ×8,400. (B) H. somnus 8025 organisms in close proximity to endothelial cells. Magnification, ×29,000. (C) Control endothelial cells with normal nuclear morphology. Magnification, ×10,800. Bar = 1 μm.