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. 2023 Jan 2;42:2. doi: 10.1186/s13046-022-02584-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — GO enrichment analysis for differentially-expressed genes (DEGs). (a-c) DEGs were defined as p.adj < 0.05 and fold changes ≥|1.5| in the comparisons of PCSK9 vs EV and Q152H vs EV, and fold change ≥|2| for D374Y vs EV. Over-representation of genes among these DEGs in GO events was analyzed. Top 20 enrichments are presented; unique enrichments are marked with red