Table 3.
Values of aTGA parameters according to vital status at Day 90 (D90). AUC: area under the receiver operating characteristic curve. OR: odds ratio.
| Survival, D90 |
||||||
|---|---|---|---|---|---|---|
| THROMBIN GENERATION ASSAY TGA, parameters | Yes: N=154a | No: N=20a | Pb | AUC | OR, 95 % C.I. | Pc |
| Without thrombomodulin, TM- | ||||||
| Lag time (LT_TM-), min. | 3.9 (2.4) | 4.6 (2.4) | 0.3 | 0.579 (0.438–0.719) | 1.08 (0.90–1.27) | 0.3 |
| Normalised LT_TM- | 1.9 (1.2) | 2.2 (1.1) | 0.4 | 0.559 (0.404–0.715) | 1.15 (0.78–1.60) | 0,4 |
| Velocity index (V_TM-), nmol.min.−1 | 190.9 (116.5) | 216.1 (166.1) | 0.8 | 0.479 (0.312–0.647) | 1.00 (1.00–1.01) | 0.4 |
| Normalised V_TM- | 177.4 (109.3) | 192.9 (147.4) | 0.9 | 0.489 (0.313–0.665) | 1.00 (1.00–1.00) | 0.6 |
| Thrombin peak height (PH_TM-), nmol.L−1 | 278.1 (100.7) | 273.6 (136.0) | > 0.9 | 0.491 (0.323–0.660) | 1.00 (1.00–1.00) | 0.9 |
| Normalised PH_TM-, | 133.0 (48.8) | 126.7 (63.5)) | 0.9 | 0.511 (0.338–0.684) | 1.00 (0.99–1.01) | 0.6 |
| Time to peak (TTP_TM-), min. | 6.2 (2.9) | 7.0 (4.0) | 0.7 | 0.530 (0.373–0.687) | 1.06 (0.96–1.10) | 0.3 |
| Normalised TTP_TM, | 1.4 (0.7) | 1.6 (0.9) | 0.7 | 0.528 (0.364–0.692) | 1.28 (0.69–2.18) | 0.3 |
| Start tail (ST_TM-), min. | 19.6 (5.6) | 21.2 (10.1) | 0.8 | 0.517 (0.361–0.672) | 1.03 (0.96–1.10) | 0.3 |
| Normalised ST_TM- | 1.0(0.3) | 1.1 (0.5) | 0.6 | 0.565 (0.395–0.736) | 1.91 (0.52–5.88) | 0.3 |
| Endogenous thrombin potential (ETP_TM-), nmol.min. | 1437.5 (379.5) | 1325.5 (496.3) | 0.5 | 0.452 (0.292–0.612) | 1.00 (1.00–1.00) | 0.2 |
| Normalised ETP_TM- | 111.2 (29.5) | 101.3 (38.1) | 0.4 | 0.537 (0.375–0.700) | 0.99 (0.97–1.01) | 0.2 |
| With thrombomodulin, TM+ | ||||||
| Lag time (LT_TM+), min. | 4.6 (2.2) | 5.2 (2.5) | 0.3 | 0.576 (0.388–0.719) | 1.11 (0.89–1.33) | 0.3 |
| Velocity index (V_TM+), nmol.min.−1 | 173.3 (124.7) | 211.3 (166.3) | 0.5 | 0.550 (0.383–0.717) | 1.00 (1.00–1.01) | 0.3 |
| Thrombin peak height (PH_TM+), nmol.L−1 | 215.2 (112.8) | 235.0 (135.3) | 0.5 | 0.553 (0.387–0.718) | 1.00 (1.00–1.01) | 0.5 |
| Time to peak (TTP_TM+), min. | 6.5 (2.5) | 7.1 (3.1) | 0.6 | 0.542 (0.385–0.699) | 1.08 (0.89–1.33) | 0.3 |
| Start tail (ST_TM+), min. | 16.1 (2.9) | 16.8 (3.3) | 0.3 | 0.576 (0.413–0.739) | 1.07 (0.90–1.23) | 0.4 |
| Endogenous thrombin potential (ETP_TM+), nmol.min. | 874.6 (424.6) | 926.1 (499.7) | 0.6 | 0.542 (0.376–0.708) | 1.00 (1.00–1.00) | 0.6 |
| Thrombomodulin effect on TGA | ||||||
| (ETP_TM+: ETP_TM-) ratio | 0.6 (0.2) | 0.6 (0.3) | 0.5 | 0.552 (0.388–0.715) | 1.84 (0.20–19.3) | 0.6 |
a
Mean (SD).
b
Wilcoxon rank sum test.
c
Wald test for OR = 1.