Table 4.
Values of aTGA parameters in patients initially admitted to a medical ward, according to the need for later transfer to an ICU due to clinical worsening. AUC: area under the receiver operating characteristic curve. OR: odds ratio.
| Transfer to ICU after an initial admision into a medicine ward |
||||||
|---|---|---|---|---|---|---|
| THROMBIN GENERATION ASSAY TGA, parameters | No, N=87a | Yes, N=42a | Pb | AUC | OR, 95 % C.I. | Pc |
| Without thrombomodulin, TM- | ||||||
| Lag time (LT_TM-), min. | 3.8 (2.8) | 4.1 (2.0) | 0.2 | 0.576 (0.464–0.689) | 1.04 (0.88–1.22) | 0.6 |
| Normalised LT_TM- | 1.9 (1.5) | 2.0 (0.9) | 0.2 | 0.571 (0.448–0.694) | 1.07 (0.76–1.50) | 0.7 |
| Velocity index (V_TM-), nmol.min.−1 | 167.6 (105.1) | 217.4 (135.9) | 0.040 | 0.620 (0.498–0.742) | 1.00 (1.00–1.01) | 0.05 |
| Normalised V_TM- | 159.5 (107.4) | 193.2 (119.6) | 0.086 | 0.605 (0.478–0.732) | 1.00 (1.00–1.01) | 0.2 |
| Thrombin peak height (PH_TM-), nmol.L−1 | 260.3 (94.9) | 288.65(112.9) | 0.050 | 0.615 (0.491–0.739) | 1.00 (1.00–1.01) | 0.2 |
| Normalised PH_TM- | 125.9 (48.2) | 134.9 (53.6) | 0.15 | 0.589 (0.462–0.715) | 1.00 (1.00–1.01) | 0.4 |
| Time to peak (TTP_TM-), min. | 6.2 (3.4) | 6.4 (3.3) | 0.8 | 0.518 (0.397–0.640) | 1.02 (0.89–1.15) | 0.7 |
| Normalised TTP_TM- | 1.4 (0.9) | 1.5 (0.7) | > 0.9 | 0.504 (0.375–0.633) | 1.09 (0.62–1.84) | 0.7 |
| Start tail (ST_TM-), min. | 19.9 (5.9) | 20.0 (8.8) | 0.2 | 0.573 (0.452–0.694) | 1.00 (0.94–1.06) | > 0.9 |
| Normalised ST_TM- | 1.1 (0.3) | 1.1 (0.5) | 0.5 | 0.545 (0.418–0.673) | 1.19 (0.38–3.44) | 0.7 |
| Endogenous thrombin potential (ETP_TM-), nmol.min. | 1407.9 (389.0) | 1388.9 (401.4) | > 0.9 | 0.504 (0.389–0.618) | 1.00 (1.00–1.00) | 0.8 |
| Normalised ETP_TM- | 108.9 (29.7) | 107.6 (31.5) | > 0.9 | 0.499 (0.376–0.621) | 0.98 (0.97–1.00) | 0.8 |
| With thrombomodulin, TM+ | ||||||
| Lag time (LT_TM+), min. | 4.4 (2.2) | 4.6 (1.7) | 0.2 | 0.573 (0.456–0.689) | 1.17 (0.89–1.49) | 0.7 |
| Velocity index (V_TM+), nmol.min.−1 | 141.2 (108.2) | 208.8 (132.6) | 0.007 | 0.665 (0.546–0.783) | 1.00 (1.00–1.01) | 0.06 |
| Thrombin peak height (PH_TM+), nmol.L−1 | 182.9 (100.9) | 245.8 (110.0) | 0.003 | 0.680 (0.562–0.798) | 1.00 (1.00–1.01) | 0.05 |
| Time to peak (TTP_TM+), min. | 6.4 (2.5) | 6.3 (2.0) | 0.8 | 0.487 (0.364–0.609) | 1.00 (0.82–1.18) | > 0.9 |
| Start tail (ST_TM+), min. | 15.9 (2.8) | 15.5 (1.9) | 0.7 | 0.480 (0.363–0.597) | 1.00 (0.76–1.11) | 0.5 |
| Endogenous thrombin potential (ETP_TM+), nmol.min. | 752.4 (386.0) | 952.0 (392.7) | 0.008 | 0.663 (0.542–0.784) | 1.00 (1.00–1.00) | 0.05 |
| Thrombomodulin effect on TGA | ||||||
| (ETP_TM+: ETP_TM-) ratio | 0.5 (0.2) | 0.6 (0.2) | 0.009 | 0.660 (0.541–0.799) | 15.5 (2.15–132) | 0.009 |
a
Mean (SD).
b
Wilcoxon rank sum test.
c
Wald test for OR = 1.