Table 5.
Values of aTGA parameters in patients according to the occurrence of any thrombotic event diagnosed during hospital stay.
AUC: area under the receiver operating characteristic curve. OR: odds ratio.
| Thrombotic event during hospital stay |
||||||
|---|---|---|---|---|---|---|
| THROMBIN GENERATION ASSAY TGA, parameters | No, N=170a | Yes, N=9a | Pb | AUC | OR, 95 % C.I. | pc |
| Without thrombomodulin, TM- | ||||||
| Lag time (LT_TM-), min. | 4.0 (2.4) | 4.3 (1.7) | 0.4 | 0.609 (0.393–0.825) | 1.05 (0.98, 1.27) | 0.7 |
| Normalised LT_TM- | 1.9 (1.2) | 2.1 (0.8) | 0.5 | 0.590 (0.349–0.831) | 1.08 (0.43, 1.59) | 0.8 |
| Velocity index (V_TM-), nmol.min.−1 | 191.9 (120.8) | 236.7 (151.8) | 0.4 | 0.592 (0.266–0.918) | 1.00 (1.00, 1.01) | 0.4 |
| Normalised V_TM- | 178.2 (113.0)) | 211.6 (128.3) | 0.5 | 0.591 (0.268–0.914) | 1.00 (1.00, 1.01) | 0.6 |
| Thrombin peak height (PH_TM-), nmol.L−1 | 275.8 (102.4) | 319.2(142.6) | 0.3 | 0.627 (0.291–0.963) | 1.00 (1.00,1.01) | 0.3 |
| Normalised PH_TM- | 131.7 (49.8) | 148.8 (64.3) | 0.3 | 0.626 (0.288–0.965 | 1.01 (0.99, 1.02) | 0.4 |
| Time to peak (TTP_TM-), min. | 6.2 (3.1) | 6.5 (2.5) | 0.9 | 0.479 (0.210–0.748) | 1.03 (0.71, 1.20) | 0.8 |
| Normalised TTP_TM- | 1.4(0.7) | 1.5(0.6) | 0.9 | 0.492 (0.218–0.765) | 1.11 (0.23, 2.16) | 0.8 |
| Start tail (ST_TM-), min. | 19.7 (6.3) | 19.7 (6.3) | 0.9 | 0.519 (0.232–0.806) | 1.00 (0.84, 1.10) | > 0.9 |
| Normalised ST_TM- | 1.0 (0.3) | 1.1(0.4) | 0.8 | 0.530 (0.236–0.823) | 1.11 (0.004, 5.85) | > 0.9 |
| Endogenous thrombin potential (ETP_TM-), nmol.min. | 1416.5 (392.6) | 1541.7 (392.5) | 0.3 | 0.620 (0.359–0.880) | 1.00 (1.00, 1.00) | 0.4 |
| Normalised ETP_TM- | 109.5 (30.6) | 118.1 (28.3) | 0.4 | 0.611 (0.354–0.868) | 0.01 (0.98, 1.04) | 0.5 |
| With thrombomodulin, TM+ | ||||||
| Lag time (LT_TM+), min. | 4.6 (2.2) | 6.2 (3.5) | 0.2 | 0.651 (0.407–0.894) | 1.11 (0.89, 1.33) | 0.3 |
| Velocity index (V_TM+), nmol.min.−1 | 175.7 (127.9) | 196.2 (156.2) | 0.7 | 0.550 (0.215–0.886) | 1.00 (1.00, 1.01) | 0.3 |
| Thrombin peak height (PH_TM+), nmol.L−1 | 215.7 (112.3) | 230.6 (163.9) | 0.6 | 0.558 (0.218–0.898) | 1.00 (1.00, 1.01) | 0.5 |
| Time to peak (TTP_TM+), min. | 6.4 (2.5) | 8.4 (4.5) | 0.4 | 0.613 (0.355–0.871) | 1.08 (0.89, 1.26) | 0.4 |
| Start tail (ST_TM+), min. | 16.0 (2.8) | 18.8 (4.7) | 0.11 | 0.694 (0.44–0.944) | 1.07 (0.90, 1.23) | 0.4 |
| Endogenous thrombin potential (ETP_TM+), nmol.min. | 871.8 (418.2) | 949.9 (678.4) | 0.6 | 0.556 (0.210–0.902) | 1.00 (1.00, 1.00) | 0.6 |
| Thrombomodulin effect on TGA | ||||||
| (ETP_TM+: ETP_TM-) ratio | 0.6 (0.2) | 0.6 (0.4) | >0.9 | 0.515 (0.172–0.858) | 0.64 (0.02–26.6) | 0.8 |
a
Mean (SD).
b
Wilcoxon rank sum test.
c
Wald test for OR = 1.