Table 3.
Comparison of Clinical Characteristics of All Patients with ABPA Between the Death and Survival Groups
| Survival | P value | ||
|---|---|---|---|
| Yes (n=50) | No (n=11) | ||
| Age, years | 52.98±17.37 | 73.00±10.02 | 0.001 |
| Male | 22(44.00%) | 9(81.82%) | 0.023 |
| Smokers | 12(24.00%) | 9(81.82%) | 0.001 |
| Pack-years of smoking | 0(0–0) | 30(15–50) | <0.001 |
| Duration of ABPA, in months | 262.50(89.00–610.75) | 165.00(49.00–517.00) | 0.800 |
| BMI (kg/m2) | 23.00±3.54 | 21.13±2.73 | 0.107 |
| Peripheral blood cells | |||
| Leukocyte, × 109/L | 8.52±3.33 | 10.91±4.98 | 0.058 |
| Neutrophil, × 109/L | 5.09±3.01 | 7.33±2.85 | 0.030 |
| Neutrophil, % | 56.68±16.52 | 61.23±24.4 | 0.461 |
| Eosinophil, × 109/L | 0.48(0.09–0.80) | 0.70(0.06–1.75) | 0.968 |
| Eosinophil, % | 7.50(1.35–11.24) | 6.90(0.60–15.85) | 0.750 |
| Inflammatory indicator | |||
| NLR | 1.97(1.41–5.88) | 6.50(2.96–14.28) | 0.002 |
| CRP, mg/L | 3.03(0.98–10.96) | 48.16(9.72–126.7) | <0.001 |
| ESR, mm/h | 13.50(5.00–26.50) | 28.00(15.00–67.50) | 0.030 |
| Immunological tests | |||
| Total IgE, IU/mL | 2324.50(1276.25–2500.00) | 1927.00(1101.00–2500.00) | 0.526 |
| Sp-IgE, kUA/L | 2.22(0.55–14.03) | 3.5(0.73–6.62) | 0.219 |
| Comorbidity | |||
| Asthma | 45(90.00%) | 7(63.64%) | 0.078 |
| COPD | 3(6.00%) | 7(63.64%) | <0.001 |
| Allergic rhinitis | 30(60.00%) | 2(18.18%) | 0.012 |
| Spirometry | |||
| FEV1/FVC | 62.62±16.12 | 53.00±14.2 | 0.077 |
| FEV1/pred | 63.11±25.60 | 48.07±26.27 | 0.095 |
| PEF, L/s | 4.68(3.31–6.53) | 2.71(2.35–3.67) | 0.027 |
| PEF, % | 73.50(48.83–94.48) | 39.6(30.55–56.90) | 0.024 |
| DLCO, % | 76.41±23.51 | 57.57±10.62 | 0.014 |
| DLCO/VA, mmol/min/kPa/L | 1.48(1.24–1.61) | 1.04(0.78–1.15) | <0.001 |
| Arterial blood gas | |||
| PaO2, mmHg | 76.46±13.15 | 72.91±10.14 | 0.417 |
| PaCO2, mmHg | 41.50(38.75–44.25) | 40.00(39.00–42.5) | 0.326 |
| SaO2, % | 96.00(94.00–97.00) | 95.00(93.50–97.00) | 0.567 |
| Treatment | |||
| Glucocorticoids | 43(86.00%) | 11(100.00%) | 0.426 |
| Antifungal Drugs | 34(68.00%) | 7(63.64%) | 1.000 |
Abbreviations: BMI, Body mass index; CRP, C-reactive protein; DLCO, Diffusion capacity of carbon monoxide; VA, Alveolar volume; ESR, Erythrocyte sedimentation rate; FEV1/FVC, Forced expiratory volume in one second (FEV1)/forced vital capacity (FVC); FEV1/pred, Percentage of FEV1 predicted; IgE, Immunoglobulin E; NLR, Neutrophil-to-lymphocyte ratio; PEF, Peak expiratory flow percentage; PaO2, Partial arterial oxygen pressure; PaCO2, Partial arterial pressure of carbon dioxide; SaO2, Oxygen saturation; Sp-IgE, Aspergillus fumigatus specific IgE.