Table 5.
C‐index and 95% CI of the Nomogram and Staging Systems (RFS)
| Score | C-Index | |||||
|---|---|---|---|---|---|---|
| Training Cohort | P | Internal Validation Cohort | P | External Validation Cohort | P | |
| nomogram | 0.78 (0.76–0.79) | —— | 0.77 (0.75–0.79) | —— | 0.80 (0.78–0.81) | —— |
| AJCC | 0.62 (0.60–0.63) | <0.001 | 0.64 (0.62–0.66) | <0.001 | 0.62 (0.60–0.63) | <0.001 |
| Okuda | 0.60 (0.59–0.61) | <0.001 | 0.60 (0.59–0.61) | <0.001 | 0.58 (0.57–0.59) | <0.001 |
| JIS | 0.60 (0.58–0.61) | <0.001 | 0.61 (0.59–0.63) | <0.001 | 0.61 (0.59–0.62) | <0.001 |
| CLIP | 0.61 (0.59–0.62) | <0.001 | 0.61 (0.59–0.63) | <0.001 | 0.59 (0.57–0.61) | <0.001 |
| BCLC | 0.56 (0.55–0.57) | <0.001 | 0.53 (0.51–0.54) | <0.001 | 0.52 (0.51–0.53) | <0.001 |
Abbreviations: AJCC 7th, the American Joint Committee on Cancer seventh edition; BCLC, Barcelona Clinic Liver Cancer; CLIP, Modified Cancer of the Liver Italian Program; JIS, Japan Integrated Staging Score.