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(A) ChIP analysis of METTL3 binding to p53 sites in p53 target gene loci, relative to input, in dox-treated E1A;HRasG12V MEFs.
(B) ChIP analysis of METTL3 binding to p53 sites in p53 target gene loci, relative to input, in dox-treated E1A;HRasG12V wild-type and p53−/− MEFs. In (A) and (B), IgG serves as a negative control antibody, and representative analysis from two biological replicates is shown.
