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. 2022 Dec 19;13:1061394. doi: 10.3389/fimmu.2022.1061394

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Copyright © 2022 Yi, Li, Niu, Wu, Zhao and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TGF-β signaling-targeted antitumor agents. At present, TGF-β signaling has been a hot therapeutic target for cancer investigators, and enormous efforts have been expended on the development of TGF-β-targeted agents. (A) TGF-β blockade strategies, including monoclonal antibodies (containing bispecific antibodies), ligand traps (containing bi-functional proteins), receptor kinase inhibitors, vaccines, and antisense oligonucleotides, are under clinical evaluation. (B) The structure of fusion protein M7824. (C) The structure of bispecific antibody YM101.