Skip to main content
. Author manuscript; available in PMC: 2023 Jan 2.
Published in final edited form as: Cell Rep. 2022 Apr 26;39(4):110730. doi: 10.1016/j.celrep.2022.110730

Figure 3. Epigenetic reprogramming by liver-specific 4F expression.

Figure 3.

(A) GO analysis for differentiation-expressed genes in RNA-seq.

(B) Heatmap for epigenetic modifiers in Hep-4F mice.

(C) Genome browser view of the ATAC-seq data at the indicated gene loci.

(D) Expression levels of Dppa3 and L1td1 genes in Dox-treated Hep-4F mice. Data were extracted from RNA-seq (Figure 2). Data represent the mean (n = 2; biological replicates). FPKM, fragments per kilobase of exon per million mapped fragments.

(E) Bisulfite sequencing of the Dppa3 promoter and distal enhancer of Oct-3/4 with the liver samples collected from the mice treated with or without Dox for 2 days.