Table 3.
Means or Medians of Continuous Quantitative Variables According to Thyroid Regulation Groups
| Variables |
N
|
Low PTFQI |
Combined median PTFQI |
High PTFQI |
p-Heter 5 groups |
p-Trend 3 groups |
||
|---|---|---|---|---|---|---|---|---|
| Primary subhypothyroidism |
Median PTFQI |
Primary subhyperthyroidism |
||||||
| |
|
% [n] |
% [n] |
% [n] |
% [n] |
% [n] |
|
|
| (N = 58) | (N = 71) | (N = 53) | (N = 59) | (N = 55) | ||||
| Age | 296 | 54.3 (16.3) | 61.2 (15.9) | 61.8 (14.7) | 66.3 (16.1) | 67.6 (15.4) | ||
| 0.00 (Ref.) | 6.64 [1.19 to 12.10] | 7.48 [1.63 to 13.32] | 12.03 [6.34 to 17.72] | 13.47 [7.67 to 19.26] | <0.01 | <0.01 | ||
| Weight | 247 | 75.6 (16.5) | 75.9 (17.2) | 76.7 (15.3) | 75.1 (19.3) | 73.7 (14.8) | ||
| 0.00 (Ref.) | 0.79 [−5.47 to 7.06] | 0.78 [−5.86 to 7.41] | −0.55 [−7.18 to 6.08] | −1.93 [−8.71 to 4.85] | 0.92 | 0.46 | ||
| Height | 240 | 164.9 (7.4) | 161.5 (9.1) | 162.9 (8.2) | 162.4 (11.2) | 162.5 (9.6) | ||
| 0.00 (Ref.) | −2.97 [−5.56 to −0.38] | −2.24 [−4.96 to 0.49] | −2.05 [−4.77 to 0.68] | −2.22 [−4.99 to 0.54] | 0.26 | 0.09 | ||
| BMI | 240 | 27.7 (5.5) | 29.3 (6.1) | 28.9 (5.8) | 28.7 (7.6) | 27.9 (5.4) | ||
| 0.00 (Ref.) | 1.56 [−0.92 to 4.04] | 1.08 [−1.53 to 3.68] | 0.91 [−1.69 to 3.52] | 0.12 [−2.53 to 2.77] | 0.70 | 0.97 | ||
| SBP | 254 | 125.5 (14.3) | 127.8 (18.8) | 132.5 (16.2) | 132.9 (16.6) | 134.8 (18.2) | ||
| 0.00 (Ref.) | 1.69 [−4.76 to 8.14] | 5.58 [−1.25 to12.41] | 4.56 [−2.21 to 11.33] | 6.03 [−1.02 to 13.09] | 0.34 | 0.08 | ||
| DBP | 254 | 77.4 (8.5) | 74.9 (9.6) | 77.0 (10.3) | 76.0 (10.4) | 74.5 (9.6) | ||
| 0.00 (Ref.) | −2.25 [−6.03 to 1.53] | −0.12 [−4.12 to 3.88] | −0.77 [−4.74 to 3.19] | −2.13 [−6.27 to 2.00] | 0.64 | 0.26 | ||
| Pulse pressure | 254 | 48.1 (11.2) | 53.0 (15.7) | 55.5 (14.4) | 56.9 (16.2) | 60.3 (17.1) | ||
| 0.00 (Ref.) | 3.94 [−1.56 to 9.44] | 5.71 [−0.12 to 11.53] | 5.33 [−0.44 to 11.11] | 8.17 [2.15 to 14.18] | 0.11 | 0.01 | ||
| Urea* | 294 | 34.0 (29.0, 42.8) | 34.0 (29.0, 42.0) | 35.0 (29.0, 43.0) | 38.0 (32.2, 45.8) | 39.0 (32.2, 48.8) | <0.01a | 0.06b |
| Creatinine* | 296 | 0.7 (0.6, 0.9) | 0.8 (0.6, 0.9) | 0.8 (0.6, 1.0) | 0.8 (0.6, 0.9) | 0.9 (0.7, 1.1) | <0.01a | 0.01b |
| Uric acid | 294 | 5.2 (1.5) | 5.6 (1.6) | 5.6 (1.6) | 5.5 (2.0) | 5.9 (1.7) | ||
| 0.00 (Ref.) | 0.37 [−0.19 to 0.94] | 0.27 [−0.33 to 0.88] | −0.02 [−0.62 to 0.57] | 0.31 [−0.30 to 0.93] | 0.52 | 0.19 | ||
| Total cholesterol | 296 | 202.5 (37.7) | 196.1 (36.0) | 197.9 (35.9) | 186.3 (41.7) | 180.3 (48.9) | ||
| 0.00 (Ref.) | −8.40 [−22.14 to 5.33] | −4.42 [−19.14 to 10.31] | −14.58 [−29.18 to 0.02] | −19.90 [−34.86 to −4.94] | 0.07 | <0.01 | ||
| HDL-cholesterol | 241 | 54.4 (13.5) | 49.8 (13.4) | 50.0 (12.9) | 50.5 (11.4) | 50.3 (12.4) | ||
| 0.00 (Ref.) | −3.77 [−8.60 to 1.05] | −3.82 [−8.97 to 1.32] | −2.10 [−7.22 to 3.02] | −1.66 [−6.94 to 3.62] | 0.521 | 0.680 | ||
| Triglycerides* | 296 | 96.0 (75.0, 132.8) | 113.0 (81.0, 155.5) | 109.0 (74.0, 180.0) | 95.0 (73.0, 127.0) | 121.0 (79.0, 138.5) | 0.85a | 0.19b |
| LDL-cholesterol | 232 | 127.6 (31.7) | 119.4 (31.5) | 117.2 (27.9) | 113.6 (38.9) | 110.7 (44.7) | ||
| 0.00 (Ref.) | −5.82 [−19.38 to 7.75] | −8.85 [−23.25 to 5.55] | −8.11 [−22.26 to 6.04] | −9.46 [−24.30 to 5.38] | 0.70 | 0.08 | ||
| NoHDL-cholesterol | 240 | 148.9 (33.9) | 145.9 (35.4) | 144.5 (32.3) | 135.3 (40.6) | 134.2 (45.9) | ||
| 0.00 (Ref.) | −1.54 [−15.98 to 12.90] | −3.30 [−18.68 to 12.08] | −9.41 [−24.82 to 5.99] | −9.32 [−25.11 to 6.47] | 0.66 | 0.11 | ||
| AST* | 293 | 21.0 (19.0, 28.0) | 22.0 (18.0, 27.8) | 21.5 (18.0, 25.2) | 19.0 (16.0, 23.5) | 25.0 (19.5, 30.5) | 0.89a | <0.01b |
| ALT* | 296 | 19.0 (14.2, 28.0) | 19.0 (13.0, 26.0) | 17.0 (14.0, 22.0) | 17.0 (12.5, 23.0) | 21.0 (14.0, 29.5) | 0.86a | 0.20b |
| GGT* | 260 | 22.5 (17.2, 33.8) | 21.0 (17.0, 33.0) | 22.0 (16.0, 34.5) | 23.0 (16.0, 31.0) | 30.0 (20.0, 76.5) | 0.07a | 0.03b |
| LDH* | 243 | 186.5 (158.5, 214.5) | 186.0 (169.0, 207.5) | 188.0 (162.0, 210.5) | 167.0 (146.5, 217.0) | 200.0 (171.5, 244.8) | 0.24a | 0.05b |
| Fasting glucose* | 296 | 94.5 (88.2, 105.2) | 92.0 (87.0, 104.0) | 96.0 (88.0, 111.0) | 100.0 (87.0, 114.0) | 97.0 (84.0, 132.5) | 0.21a | 0.71b |
| HbA1c* | 106 | 5.8 (5.5, 6.4) | 6.2 (5.5, 7.3) | 6.0 (5.8, 7.1) | 6.4 (5.8, 7.3) | 6.1 (5.5, 7.2) | 0.53a | 0.70b |
| Hematocrit | 262 | 42.1 (3.1) | 41.4 (3.9) | 41.9 (3.5) | 41.8 (4.2) | 41.1 (5.1) | ||
| 0.00 (Ref.) | −0.09 [−1.47 to 1.29] | 0.18 [−1.31 to 1.67] | −0.17 [−1.61 to 1.27] | −0.90 [−2.37 to 0.58] | 0.66 | 0.27 | ||
| Hemoglobin | 262 | 14.1 (1.1) | 13.8 (1.4) | 14.0 (1.3) | 14.0 (1.5) | 13.7 (1.9) | ||
| 0.00 (Ref.) | −0.04 [−0.52 to 0.45] | 0.05 [−0.47 to 0.58] | −0.02 [−0.52 to 0.49] | −0.32 [−0.84 to 0.20] | 0.64 | 0.27 | ||
| Red blood cells | 262 | 4.7 (0.4) | 4.6 (0.5) | 4.7 (0.4) | 4.7 (0.5) | 4.6 (0.6) | ||
| 0.00 (Ref.) | 0.01 [−0.16 to 0.17] | 0.07 [−0.11 to 0.25] | −0.01 [−0.18 to 0.17] | −0.08 [−0.26 to 0.09] | 0.59 | 0.39 | ||
| White blood cells | 262 | 6.9 (2.0) | 7.1 (1.8) | 7.4 (2.5) | 7.2 (2.1) | 7.2 (2.2) | ||
| 0.00 (Ref.) | 0.33 [−0.45 to 1.11] | 0.61 [−0.23 to 1.46] | 0.43 [−0.38 to 1.24] | 0.42 [−0.41 to 1.25] | 0.69 | 0.38 | ||
| Lymphocytes | 262 | 31.6 (9.3) | 34.8 (9.4) | 32.1 (7.4) | 28.8 (10.2) | 30.8 (8.8) | ||
| 0.00 (Ref.) | 2.90 [−0.52 to 6.32] | 0.35 [−3.35 to 4.06] | −2.87 [−6.44 to 0.70] | −0.79 [−4.44 to 2.86] | 0.02 | 0.75 | ||
| Neutrophils | 262 | 56.8 (10.3) | 52.8 (9.4) | 55.6 (9.0) | 59.9 (11.5) | 56.8 (8.9) | ||
| 0.00 (Ref.) | −3.64 [−7.34 to 0.06] | −0.94 [−4.95 to 3.07] | 3.57 [−0.30 to 7.43] | 0.48 [−3.47 to 4.43] | <0.01 | 0.88 | ||
Data are expressed in mean (standard deviation). For nonnormal variables (*), data are expressed in median and interquartile range. Adjusted means [CI] from models adjusted for age and sex, referenced to the Low PTFQI group. p-Heter is the p-value for testing differences among groups. p-Trend is the p-value from a regression model that includes group as a numerical value.
*
Nonparametric variables.
a
Kruskal–Wallis test.
b
Spearman's Rho test.
DBP, diastolic blood pressure; HDL, high-density lipoprotein; HbA1c, glycosylated hemoglobin; LDL, low-density lipoprotein; Ref., reference; SBP, systolic blood pressure.