Table 3.
Links Between Functional Connectivity Data and Postsurgical Seizure Outcome
| Authors | Population | Recording modality | Methods | Main results |
|---|---|---|---|---|
| Schevon et al (2007) | Nine patients with neocortical epilepsy | ECoG (during presurgical monitoring) | Mean phase coherence | Complete resection of area of local hypersynchrony associated with good outcome |
| Ortega et al (2008) | Twenty-nine patients with TLE | ECoG (during surgery) | Linear correlation, mutual information, and phase synchronization | No correlation between complete resection of cluster of local hypersynchrony and postsurgical outcome |
| Antony et al (2013) | Twenty-three patients with TLE | SEEG | Linear correlation | Better outcome if weaker overall FC and more homogenous overall FC (less outlier with high FC) |
| Lagarde et al (2018) | Fifty-nine patients with FCD or NDT (20 TLE) | SEEG | Nonlinear correlation (h2) | Worse outcome is higher FC within NIZ |
| Grobelny et al (2018) | Thirty-six patients | ECoG (during presurgical monitoring) | Granger causality | Worse outcome if higher overall betweenness centrality and more outlier with high values |
| Goodale et al (2020) | Fifteen patients (12 TLE) | SEEG | Imaginary coherence | Better outcome if higher FC within-RZ |
| Shah et al (2019b) | Twenty-seven patients (18 TLE) | ECoG + depth electrodes | Linear correlation | Better outcome if higher FC within RZ Better outcome with higher overlap between RZ and nodes with the highest FC |
| Guo et al (2020) | Twenty-five patients (10 TLE) | SEEG | CCEP | Better outcome if higher FC within EZ |
| Paulo et al (2022) | Thirty-two patients (18 TLE) | SEEG | Imaginary coherence, partial directed coherence (in alpha band) | No difference in EZ FC between patients being Engel I or not |
| Jiang et al (2022) | Twenty-seven patients (23 TLE) | SEEG | Directed transfer function, cross-frequency directionality | Larger within-frequency information flow asymmetry between EZ and NIZ is associated with favorable outcome |
Studies are presented in chronological order. For studies using ECoG recordings, we precise if the recordings were performed during a surgery procedure (with anesthesia) or long-term monitoring.