Table 3.
Patient Characteristics and Outcomes of the Recurrence-Free Survival Cohort and by Molecular Risk Group
| Total (n = 92) | MRG |
p | |||
|---|---|---|---|---|---|
| Low (n = 18) | Intermediate (n = 63) | High (n = 11) | |||
| Mean age (SD), year | 52.3 (17.7) | 52.5 (19.1) | 49.3 (16.9) | 69.0 (9.3) | 0.002 |
| Female | 56 (60.9%) | 11 (61.1%) | 38 (60.3%) | 7 (63.6%) | 0.98 |
| Median nodule size (range), cm | 2.0 (0.6–11.1) | 2.5 (1.4–6.1) | 1.7 (0.6–6.7) | 4.1 (1.2–11.1) | <0.001 |
| TI-RADS score | 0.002 | ||||
| 3 | 16 (17.4%) | 7 (38.9%) | 7 (11.1%) | 2 (18.2%) | |
| 4 | 40 (43.5%) | 9 (50.0%) | 31 (49.2%) | 0 (0.0%) | |
| 5 | 32 (34.8%) | 2 (11.1%) | 22 (34.9%) | 8 (72.7%) | |
| NA | 4 (4.4%) | 0 (0.0%) | 3 (4.8%) | 1 (9.1%) | |
| Total thyroidectomy | 67 (72.8%) | 10 (55.6%) | 50 (79.4%) | 7 (62.6%) | 0.10 |
| Central node dissection | |||||
| Prophylactic | 19 (20.7%) | 4 (22.2%) | 13 (20.6%) | 2 (18.2%) | 1.00 |
| Therapeutic | 12 (13.0%) | 1 (5.6%) | 8 (12.7%) | 3 (27.3%) | 0.27 |
| Central nodal disease | 18 (19.5%) | 1 (5.6%) | 14 (22.2%) | 3 (27.3%) | 0.20 |
| Lateral nodal disease | 4 (4.4%) | 0 (0.0%) | 3 (4.8%) | 1 (9.1%) | 0.53 |
| Extrathyroidal extension | |||||
| Microscopic | 19 (20.7%) | 1 (5.6%) | 13 (20.6%) | 5 (45.5%) | 0.04 |
| Gross | 2 (2.2%) | 0 (0.0%) | 0 (0.0%) | 2 (18.2%) | 0.01 |
| ATA risk category | < 0.001 | ||||
| Low | 57 (62.0%) | 16 (88.9%) | 40 (63.5%) | 1 (9.1%) | |
| Intermediate | 24 (26.1%) | 2 (11.1%) | 19 (30.2%) | 3 (27.3%) | |
| High | 6 (6.5%) | 0 (0.0%) | 3 (4.8%) | 3 (27.3%) | |
| NA | 5 (5.4%) | 0 (0.0%) | 1 (1.6%) | 4 (36.4%) | |
| RAI | 31 (33.7%) | 4 (22.2%) | 19 (30.2%) | 8 (72.7%) | 0.01 |
| Recurrence | 12 (13.0%) | 0 (0.0%) | 6 (9.5%) | 6 (54.6%) | < 0.001 |
| Death | |||||
| All-cause | 4 (4.4%) | 1 (5.6%) | 1 (1.6%) | 2 (18.2%) | 0.05 |
| Disease specific | 1 (1.1%) | 0 (0.0%) | 0 (0.0%) | 1 (9.1%) | 0.12 |
| Mean follow-up (range), months | 51.2 (<1–470) | 51.3 (30–83) | 46.3 (4–315) | 78.6 (<1–470) | 0.29 |
ATA, American Thyroid Association; NA, not applicable; RAI, radioactive iodine; SD, standard deviation; TI-RADS, Thyroid Imaging, Reporting and Data System.