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. 2022 Dec 13;35(6):321–332. doi: 10.1089/jamp.2022.0005

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© Wade Cooper, et al., 2022. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 2. — Diagram of the INP104 product. Delivery of DHE mesylate using POD technology (INP104) involves manual actuation by the user (squeezing of the surfaces noted by the white arrows), which after priming the device draws up a precise volume of DHE mesylate (red arrows) from the liquid drug reservoir to the dose chamber. The propellant, HFA-134a (blue arrows), is directed from the propellant canister, and its release creates a pressure as the gas expands, channeling DHE mesylate through the nozzle and expelling the drug from the device and to the UNS. Subsequently, the HFA-134a propellant pushes the released DHE mesylate deeper into the UNS in a second phase of deposition. DHE, dihydroergotamine; HFA, hydrofluoroalkane; POD, Precision Olfactory Delivery.