Table 2. Positivity score of the tumor cell population and stain strength (grade) for insulinoma-associated protein 1 in cervical neuroendocrine neoplasms and non-neuroendocine neoplasms.
| No. | No. of cases with tumor cell population positivity score for INSM1 (score) | Stain strength for INSM1 (grade) | Cases with tumor cell population positive for Syn/CGA/NCAM | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 0 | 1+ | 2+ | 3+ | Syn | CGA | NCAM | |||
| NEN | |||||||||||||
| SCNEC | 8 | 0 | 1 | 1 | 6 | 0 | 1 | 0 | 7 | 6 | 4 | 4 | |
| LCNEC | 5 | 0 | 1 | 3 | 1 | 0 | 0 | 1 | 4 | 4 | 3 | 4 | |
| SCNEC+LCNEC | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | |
| NET G2 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 2 | 1 | |
| Total | 16 | 0 | 2 | 5 | 9 | 0 | 1 | 1 | 14 | 13 | 10 | 10 | |
| Positivity rate | INSM1, 15/16 (94%) (positive score, 1 to 3; stain grade, 2+/3+) | Syn, 13/16 (81.3%) | CGA, 10/16 (62.5%) | NCAM, 10/16 (62.5%) | |||||||||
| Non-NEN | |||||||||||||
| Squamous cell carcinoma | 61 | 60 | 1 | 0 | 0 | 60 | 0 | 0 | 1 | ||||
| Adenocarcinoma | 23 | 22 | 1 | 0 | 0 | 22 | 0 | 0 | 1 | ||||
| Adenosquamous carcinoma | 2 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | ||||
| CIN3 | 2 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | ||||
| Total | 88 | 86 | 2 | 0 | 0 | 86 | 0 | 0 | 2 | ||||
| Positivity rate | INSM1: 2/86 (2.3%) (positive score, 1 to 3; stain grade, 2+/3+) | ||||||||||||
NEN, neuroendocrine neoplasia; INSM1, insulinoma-associated protein 1; Syn, synaptophysin; CGA, chromogranin A; NCAM, neural cell adhesion molecule; SCNEC, small cell neuroendocrine carcinoma; LCNEC, large cell neuroendocrine carcinoma; CIN3, cervical intraepithelial neoplasia, grade 3.