TABLE 3.

Chi‐squared analysis and Fisher's exact test for grade of increased creatinine

		Grade 1	Grade 2	p			Grade 1	Grade 2	p
Age (years)				0.81	Type of endocrine therapy				0.44
	<60	82	38			AI	65	28
	≥60	48	24			Fulvestrant	59	31
Weight (kg)						TAM	3	3
	<68.5	91	37	0.16		NA	3	0
	≥68.5	39	25		Start dose of abemaciclib (mg/bid)				0.33
Menopausal status a				0.00		150	115	53
	Premenopausal	56	13			100	12	9
	Postmenopausal	74	49			50	3	0
Bone metastases status				0.18	Dose modifications				0.18
	Yes	53	19			Yes	24	6
	No	77	43			No	100	50
Osteoclast inhibitors				0.28		NA	6	6
	Bisphosphonate	42	18
	Denosumab	6	0
	Bisphosphonate/denosumab	2	1
	None	77	43
	NA	3	0

Abbreviations: AI, aromatase inhibitors; bid, bis in die; NA, not access; TAM, tamoxifen.

^a The difference between groups is significant.