Table 3.
Changes in iron-related parameters and in mineral and bone disorder-related parameters in patients from the GBA4-6 study undergoing hemodialysis
| Mean (SD) | With GASI, n = 95 | Without GASI, n = 85 | ||||
|---|---|---|---|---|---|---|
| BL | EOT | Change | BL | EOT | Change | |
| Serum iron [µg/dL] |
61.5 (21.0) |
85.5 (35.9) |
24.0 (39.6) |
58.5 (20.5) |
84.2 (38.3) |
25.6 (40.2) |
| Serum ferritin [ng/mL] |
79.51 (73.10) |
245.83 (165.33) |
166.32 (153.70) |
92.52 (88.95) |
247.69 (174.60) |
155.16 (139.47) |
| TIBC [µg/dL] |
250.8 (44.6) |
211.3 (34.6) |
− 39.5 (35.0) |
255.2 (43.6) |
215.1 (32.2) |
− 40.1 (31.3) |
| TSAT [%] |
24.94 (8.50) |
41.54 (18.57) |
16.60 (19.44) |
23.30 (8.38) |
39.32 (17.34) |
16.02 (18.81) |
| Hb [g/dL] |
10.89 (1.00) |
11.13 (1.26) |
0.24 (1.43) |
11.06 (1.07) |
11.28 (1.26) |
0.23 (1.18) |
| Serum P [mg/dL] |
5.46 (1.13) |
5.23 (1.07) |
− 0.23 (1.41) |
5.61 (1.36) |
5.64 (1.53) |
0.02 (1.69) |
| Serum cCa [mg/dL] |
9.21 (0.59) |
9.07 (0.63) |
− 0.14 (0.56) |
9.17 (0.55) |
8.86 (0.58) |
− 0.30 (0.57) |
| iPTH [pg/mL] |
151.9 (107.0) |
208.3 (130.8) |
56.3 (119.0) |
165.0 (144.6) |
227.1 (144.5) |
62.1 (129.0) |
| Ca*P [(mg/dL)2] |
50.26 (10.66) |
47.51 (10.43) |
− 2.75 (13.07) |
51.45 (12.72) |
49.84 (13.42) |
− 1.60 (14.84) |
BL baseline, Ca*P calcium–phosphate product, cCa corrected calcium, EOT end of treatment, GASI gastric acid secretion inhibitor, Hb hemoglobin, iPTH intact parathyroid hormone, P phosphate, SD standard deviation, TIBC total iron-binding capacity, TSAT transferrin saturation