Table 1.

Clinical characteristics of NF1 patients with MPNSTs harboring NTRK rearrangements

Case	Age	Location	Primary diagnosis	Metastases	Neo-adjuvant Therapy	Follow-up
1	16	Knee	MPNST ex plexiform neurofibroma	Yes (lung)	Trk-i	Aw/oD (18 months)
2	29	Sciatic nerve	MPNST ex plexiform neurofibroma	No	Radiotherapy	Aw/oD (8 years)
3	34	Quadriceps muscle	MPNST without signs of preexisting neurofibroma	No	None	Aw/oD (29 years)

Aw/oD alive without disease, Trk-i Trk-inhibitor