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. 2023 Jan 2;13:68. doi: 10.1038/s41598-022-27078-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Violin plot showing the distribution of pixel intensities from different components of a pigment epithelial detachment (PED). Pixel intensities correspond to pre-processed spectral-domain optical coherence tomography images taken from 43 eyes with neovascular age-related macular degeneration. Mutually exclusive classified components include serous, neovascular, and fibrous. Fibrovascular is the combined distribution of neovascular and fibrous tissue. Total PED is the combined distribution of serous, neovascular, and fibrous tissue. The overlap in the distributions indicates the difficulty in separating tissue types, particularly neovascular and fibrous tissue. The skewed distribution of fibrovascular tissue indicates more than one underlying tissue type.