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. 2023 Jan 2;7:1. doi: 10.1038/s41698-022-00342-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Proportion of patients with P/LP variants in GIST-associated genes in the cohort of 103 patients who received germline genetic testing. Percentages are plotted and displayed on the bar graphs. Error bars represent confidence intervals calculated by the Clopper-Pearson method. b Distribution of germline (blue) and somatic (orange) P/LP variants detected in tumor-only sequencing analysis of de-identified GISTs from 499 patients. Data from all tumors (left), KIT-mutant tumors (middle), and KIT-wildtype tumors (right) are presented. Numbers displayed on the right of each gene data on each plot represent the number of tumor samples with variants identified in each gene in that group of tumors.