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. 2022 Dec 20;13:1072202. doi: 10.3389/fphar.2022.1072202

FIGURE 2.

FIGURE 2

Combined efficacy of Molnupiravir (EIDD-2801) with GS-441524 against SARS-CoV-2 B.1.351 variant in a hamster infection model (A) Set-up of the study (B) Viral RNA levels in the lungs of control (vehicle-treated), EIDD-2801-treated (150 mg/kg, BID), GS-441524-treated (50 mg/kg, BID) and combination-treated (EIDD-2801+GS-441524 at 150 + 50 mg/kg BID) SARS-CoV-2 (B.1.351)−infected hamsters at day 4 post-infection (pi) are expressed as log10 SARS-CoV-2 RNA copies per mg lung tissue. Individual data and median values are presented. (C) Infectious viral loads in the lungs of control (vehicle-treated), EIDD-2801-treated, GS-441524-treated and combination-treated (EIDD-2801+ GS-441524) SARS-CoV-2−infected hamsters at day 4 pi are expressed as log10 TCID50 per mg lung tissue. Individual data and median values are presented. (D) Cumulative severity score from H&E stained slides of lungs from different treatment groups. Individual data and median values are presented and the dotted line represents the median score of untreated non-infected hamsters. (E) Weight change at day 4 pi in percentage, normalized to the body weight at the time of infection. Bars represent means ± SD. Data were analyzed with the Mann−Whitney U test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns = non-significant, i.e., p < 0.05). EIDD = EIDD-2801. All data [panels (B–E)] are from two independent experiments with 12 animals per group except for the combination group (n = 10). Panel (A) created by Bioredner.