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. 2023 Jan 2;12(1):1. doi: 10.1038/s41389-022-00446-y

Fig. 1. The levels of p-AKT and UHRF1 elevated in the abiraterone-refractory PCa cells.

Fig. 1

A, B The parental or abiraterone-refractory CWR22Rv1 (CWR22Rv1-R) or LNCaP (LNCaP-R) cells were treated with stepwise concentrations of abiraterone, and the IC50 values of abiraterone were calculated. C, D The protein levels of p-AKT, AKT, UHRF1, NCAM1, and SYP in the parental or abiraterone-refractory PCa cells were assessed by western blotting. E, F The expression level of UHRF1 and p-AKT were compared in the PCa tumor specimens from prostate specific PTEN−/P53−/Rb1− or PTEN− gene knockout mice. The presented results were representative of experiments repeated at least three times. Data was represented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.