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. 2022 Dec 20;13:1075986. doi: 10.3389/fendo.2022.1075986

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Copyright © 2022 Liu, Li, He, Zhao, Huang, Wang, Zheng, Zhang, Shi and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aerobic exercise decreases hepatosteatosis, lobular inflammation and fibrosis in mouse livers. (A) Representative images of liver sections stained by Oil Red O, HE and Masson staining from control, NASH and NASH+Exercise mice (original magnification, ×200). (B) Histological scores of steatoses, lobular inflammation, and hepatocyte ballooning in H&E-stained livers. (C) NAFLD activity score was calculated by the histological score of steatosis, lobular inflammation, and hepatocyte ballooning. (D) The collagen volume fraction by Masson staining. (E) Relative mRNA levels of IL-1β, TNFα and F4/80 in liver tissues from control, NASH and NASH+Exercise mice. Data are depicted in mean ± SEM. *P<0.05; ****P<0.0001.