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. 2022 Dec 20;13:1095915. doi: 10.3389/fimmu.2022.1095915

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Copyright © 2022 Gou, Liu, Liu, Luo, Qin, He and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OCA combined with 5β-CA significantly inhibited orthotopic H22 liver tumor. (A) The experimental flow chart. (B) Representative liver images in the 4 groups are shown. The tumors were outlined with an orange dashed curve. (C) The orthotopic H22 mice model was assessed by H&E images. A black dashed line outlines the border between the tumor and the non-tumor liver. (D) The liver weight, tumor weight and the ratios of tumor/liver weight from 4 groups were recorded while mice were executed. (E) The body weight variation. (F) Tumor-induced liver injury, drug-induced hepatotoxicity or drug-induced liver protective effect was assessed by serum levels of ALT and AST. Drug-induced nephrotoxicity was assessed by BUN and CREA (ns, no significance; *0.01 ≤ P value < 0.05; **0.001 ≤ P value < 0.01; ***P value < 0.001).